CREDIT AGREEMENT

        THIS CREDIT AGREEMENT (this Agreement) is entered into as of December 1, 2005, by and between MEDTOX SCIENTIFIC, INC., MEDTOX DIAGNOSTICS, INC. and MEDTOX LABORATORIES, INC., each a Delaware corporation (each individually, a Borrower), and WELLS FARGO BANK, NATIONAL ASSOCIATION (Bank). Each reference herein to Borrower shall mean each and every party, collectively and individually, defined above as a Borrower.

RECITALS

        Borrower has requested that Bank extend or continue credit to Borrower as described below, and Bank has agreed to provide such credit to Borrower on the terms and conditions contained herein.

        NOW, THEREFORE, for valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Bank and Borrower hereby agree as follows:

ARTICLE I
CREDIT TERMS

     SECTION 1.1.        LINE OF CREDIT.

    (a)        Line of Credit. Subject to the terms and conditions of this Agreement, Bank hereby agrees to make advances to Borrower from time to time up to and including November 1, 2007, not to exceed at any time the aggregate principal amount of Eight Million Dollars ($8,000,000.00) (Line of Credit), the proceeds of which shall be used for working capital. Borrowers obligation to repay advances under the Line of Credit shall be evidenced by a promissory note dated as of December 1, 2005 (Line of Credit Note), all terms of which are incorporated herein by this reference.

    (b)        Letter of Credit Subfeature. As a subfeature under the Line of Credit, Bank agrees from time to time during the term thereof to issue or cause an affiliate to issue standby and/or sight commercial letters of credit for the account of Borrower (each, a Letter of Credit and collectively, Letters of Credit). The form and substance of each Letter of Credit shall be subject to approval by Bank, in its sole discretion. No Letter of Credit shall have an expiration date subsequent to the maturity date of the Line of Credit. The undrawn amount of all Letters of Credit shall be reserved under the Line of Credit and shall not be available for borrowings thereunder. Each Letter of Credit shall be subject to the additional terms and conditions of the Letter of Credit agreements, applications and any related documents required by Bank in connection with the issuance thereof. Each drawing paid under a Letter of Credit shall be deemed an advance under the Line of Credit and shall be repaid by Borrower in accordance with the terms and conditions of this Agreement applicable to such advances; provided however, that if advances under the Line of Credit are not available, for any reason, at the time any drawing is paid, then Borrower shall immediately pay to Bank the full amount drawn, together with interest thereon from the date such drawing is paid to the date such amount is fully repaid by Borrower, at the rate of interest applicable to advances under the Line of Credit. In such event Borrower agrees that Bank, in its sole discretion, may debit any account maintained by Borrower with Bank for the amount of any such drawing.

    (c)        Borrowing and Repayment. Borrower may from time to time during the term of the Line of Credit borrow, partially or wholly repay its outstanding borrowings, and reborrow, subject to all of the limitations, terms and conditions contained herein or in the Line of Credit Note; provided however, that the total outstanding borrowings under the Line of Credit shall not at any time exceed the maximum principal amount available thereunder, as set forth above.

     SECTION 1.2.        LOAN LIMIT.

    (a)        Loan Limit. Subject to the terms and conditions of this Agreement, Bank hereby agrees to make advances to Borrower from time to time up to and including November 1, 2007, not to exceed the aggregate principal amount of Two Million Dollars ($2,000,000.00) (Loan Limit), the proceeds of which shall be used to finance the purchase of equipment. Borrowers obligation to repay each advance under the Loan Limit shall be evidenced by a promissory note executed at the time such advance is made, substantially in form acceptable to Bank (each, a Loan Limit Note and collectively, Loan Limit Notes), all terms of which are incorporated herein by this reference.

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