March 2, 2000



Walter C. Herlihy, Ph.D.

Chief Executive Officer

Repligen Corporation

117 Fourth Avenue

Needham, MA 02494



                                FINDERS AGREEMENT



Dear Sirs:



         Reference is made to our recent discussions relating to a proposed

private placement under Rule 506 of Regulation D of the Securities Act of 1933,

as amended (the "Act") of securities of Repligen Corp. (the "Company") as

hereinafter described. Based upon our discussions and representations which you

have made to us describing the Company and its principals, the present and

proposed business activities of the Company and the Company's operations and

financial condition, Paramount Capital, Inc. ("Paramount") hereby confirms in

principle its interest in acting as a finder for the Company, on a "best

efforts" basis, in connection with the private placement offering of the

Company's shares of Common Stock (the "Offering"), upon the following basic

terms and conditions:



         1. Paramount will introduce the Company to "accredited investors" as

defined in Rule 501 of Regulation D promulgated under the Act for the purchase

of up to 2,650,000 shares of common stock, par value $.01 per share (the "Common

Stock"). Each share of Common Stock will be sold at a price per share price (the

"Per Share Price") equal to eighty five percent (85%) of the average closing bid

price of the Common Stock for the fifteen (15) trading days immediately

preceding the Closing Date (as defined in paragraph 2 below) of the Offering;

provided, however, that in no event will the Per Share Price be greater than

$8.625. Further, subject to the Break-up Fee (as defined in paragraph 20 below)

the Company shall not be required to sell the Common Stock at a Price Per Share

less than $6.00. For purposes hereof, "closing bid price" shall mean, for each

trading day, the price at which the Common Stock was last exchanged on the

Nasdaq National Market during such trading day, or, if there were no

transactions on such trading day, the average of the reported closing bid and

asked prices, regular way, of the Common Stock on such trading day. "Trading

day" shall mean a day on which the relevant Nasdaq National Market is open for

the transaction of business.



         2. The closing date of the Offering will occur no later than sixty (60)

days following the execution of this Agreement, subject to extension at the

option of the Company for an additional thirty (30) days (the date of any such

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