PARENT SUPPORT AGREEMENT



      This Parent Support Agreement (the "AGREEMENT") is made and entered into

as of September 28, 2004, between Solexa Limited, a company registered in

England and Wales (the "COMPANY") and the undersigned stockholder ("HOLDER") of

Lynx Therapeutics, Inc., a Delaware corporation ("PARENT").



                                    RECITALS



      Pursuant to an Acquisition Agreement dated as of September 28, 2004 (the

"ACQUISITION AGREEMENT") by and between Parent and the Company, it is proposed

that Parent shall make the Offer and the Option Offer within the meanings set

forth in the Acquisition Agreement. Concurrently with the execution and delivery

of the Acquisition Agreement and as a condition and inducement to the Company

entering into the Acquisition Agreement, the Company has required that Holder

enter into this Agreement. The Holder is the record and beneficial owner (as

such term is defined in Rule 13d-3 of the General Rules and Regulations under

the Securities Exchange Act of 1934, as amended) of (1) such number of shares of

Parent Common Stock (the "SHARES") and (2) such number of options to purchase

Parent Common Stock (the "OPTIONS"), each as is indicated beneath Holder's

signature on the last page of this Agreement. Terms used herein and not defined

herein shall have the meaning set forth in the Acquisition Agreement.



                                    AGREEMENT



      The parties agree as follows:



      1. AGREEMENT TO RETAIN SHARES.



            (a) TRANSFER AND ENCUMBRANCE. Except as contemplated by the

Acquisition Agreement, and except as provided in Sections 1(b) or 2 below,

during the period beginning on the date hereof and ending on the earlier to

occur of (i) one hundred eighty (180) days following the First Closing Date, and

(ii) the Expiration Date (as defined below), Holder agrees not to, directly or

indirectly (x) transfer (except as may be specifically required by court order),

sell, exchange, tender, pledge, assign, contribute to the capital of any entity,

hypothecate or otherwise dispose of (including by merger, consolidation or

otherwise by operation of law) or encumber the Shares or any New Shares (as

defined below), enter into any short sale with respect to the Shares or any New

Shares, enter into or acquire an offsetting derivative contract with respect to

such Shares or any New Shares, enter into or acquire a futures or forward

contract to deliver such Shares or any New Shares or enter into any other

hedging or other derivative transaction that has the effect of materially

changing the economic benefits and risks of ownership of the Shares or any New

Shares, or to, directly or indirectly, make any offer or agreement relating

thereto, (y) grant any proxies or powers of attorney, deposit any of such Shares

or New Shares into a voting trust or enter into a voting agreement with respect

to any of such Shares or New Shares, or enter into any agreement or arrangement

providing for any of the actions described in this clause (y), or (z) take any

action that could reasonably be expected to have the effect of preventing or

disabling Holder from performing Holder's obligations under this Agreement, and

Holder has not agreed to carry out any of the foregoing matters in relation to

the Shares or any







New Shares. As used herein, the term "EXPIRATION DATE" shall mean the date of

termination of the Acquisition Agreement in accordance with the terms and

provisions thereof.



            (b) PERMITTED TRANSFERS. Section 1(a) shall not prohibit a transfer

of Shares or New Shares by Holder (i) if Holder is an individual (A) to any

member of Holder's immediate family, or to a trust for the benefit of Holder or

any member of Holder's immediate family, or (B) upon the death of Holder, or

(ii) if Holder is a partnership or limited liability company, to one or more

partners or members of Holder or to an affiliated Person under common control

with Holder; provided, however, that any such transfer pursuant to either clause

(i) or (ii) of this Section 1(b) shall be permitted only if, as a precondition

to such transfer, the transferee agrees in writing to be bound by all of the

terms of this Agreement.



            (c) NEW SHARES. Holder agrees that any shares of capital stock or

other securities of Parent that Holder purchases or with respect to which Holder

otherwise acquires record or beneficial ownership after the date of this

Agreement and prior to the earlier to occur of (i) one hundred eighty (180) days

following the First Closing Date and (ii) the Expiration Date ("NEW SHARES")

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