SECOND AMENDMENT TO DEVELOPMENT AND SUPPLY AGREEMENT



     This Second Amendment to Development and Supply Agreement ("Amendment"),

effective as of June 12, 2000, is made by and between Luminex Corporation, a

Delaware corporation ("LUMINEX"), and Bio-Rad Laboratories, Inc., a Delaware

corporation ("BIO-RAD") (LUMINEX and BIO-RAD collectively, the "Parties"), and

amends that certain Development and Supply Agreement dated as of March 19, 1999

between the Parties (as previously amended by amendment dated January 13, 2000,

the "Agreement").



     The Parties hereby agree as follows, for the purpose of amending the

Agreement in the following respects:



1.   Amendments. The Parties hereby agree to amend the Agreement in the

     following respects:



     1.1  Magnetic Bead Amendments.



          1.1.1 Section 2.1(d) of the Agreement is hereby amended to delete all

sentences in that section except the first two sentences and add the following

as the third and fourth sentences of such section:



          "Exhibit F sets forth the criteria for BIO-RAD's supply of Magnetic

          Beads to LUMINEX and LUMINEX's treatment of such Magnetic Beads. The

          tolling fees payable by BIO-RAD to LUMINEX with respect to Magnetic

          Beads shall be the prices set forth in Exhibit G (the "Magnetic Bead

          Prices")."



          1.1.2 Section 2.2 of the Agreement is hereby amended to delete the

phrase in the last sentence "or the Development Agreement."



          1.1.3 Sections 1.4, 4.2, 4.3, 4.4, 4.5, 4.8, 4.10, 4.15, 4.16 and

Article 7 of the Agreement are hereby amended to delete all instances of the

word "Standard" when preceding the word "Beads."



          1.1.4 Section 4.6(b) of the Agreement is hereby amended to delete the

last sentence of such section and replace it with the following:



          "The amounts of the tolling fees for Magnetic Beads shall be as set

          forth in Exhibit G. These Magnetic Bead Prices will be effective

          during the first [**] of this Agreement, after which time LUMINEX may,

          [**]. Such increases may occur no more frequently than [**]. Each [**]

          increase during the [**]."



          1.1.5 Section 4.9 of the Agreement is hereby amended to add the phrase

", Magnetic Bead Prices" following the phrase "Payment of the Unit Transfer

Fee."



          1.1.6 Exhibits F and G attached to this Amendment are hereby added as

Exhibits to the Agreement.



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[**] Indicates that material has been omitted and confidential treatment

requested therefor. All such material has been filed separately with the

Commission pursuant to Rule 24b-2.







{PAGE}   2





     1.2  Standard Bead Pricing Amendments.



          1.2.1 The first sentence of Section 4.6(a) of the Agreement is hereby

                amended by deleting the phrase "[**] for ever [**] units of

                Standard Beads purchased, where a "unit" of Standard Beads is

                equal to one microsphere bead ("Unit Transfer Fee") and

                substituting therefor:



          "for Beads purchased hereunder according to the prices set forth on

          Exhibit H, as amended ("Unit Transfer Fees")."



          1.2.2 All references in the Agreement to "Unit Transfer Fee" are

hereby amended to be references to "Unit Transfer Fees."



          1.2.3 Exhibit H, attached to this Amendment, is hereby added as an

Exhibit to the Agreement.



          1.2.4 Exhibit I, [**], rev. C, attached to this Amendment, is hereby

added as an Exhibit to the Agreement.



          1.2.5 The end of the first sentence of Section 9.1 is hereby amended

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