LEASE RENEWAL AMENDMENT

                                   1045179-001



         THIS LEASE RENEWAL AMENDMENT dated as of July 1, 2003 ("Amendment")

amends Schedule No. SG02 ("Schedule") to the Master Lease Agreement dated as of

September 13, 1995 ("Agreement"), such Schedule and Agreement, as the same may

have been heretofore amended or otherwise modified, are hereinafter collectively

referred to as the ("Lease") between General Electric Capital Corporation

Successor In Interest to Comdisco, Inc. as of February 25, 2002 ("Lessor") and

La Jolla Pharmaceutical Company ("Lessee"). Capitalized terms not defined herein

shall have the meanings assigned to them in the Lease.



                               W I T N E S S E T H



         WHEREAS, the term of the Lease is scheduled to expire on June 30, 2003

("Primary Term Expiration Date"); and



         WHEREAS, Lessee desires to renew the Lease pursuant to the terms set

forth herein; and



         WHEREAS, Lessor is willing to consent to such renewal pursuant to the

terms set forth herein;



         NOW, THEREFORE, in consideration of the above premises and the mutual

promises contained herein, as well as other good and valuable consideration, the

receipt and sufficiency of which is hereby acknowledged, the parties hereto,

intending to be legally bound, agree as follows:



     1.  Commencing on July 1, 2003, the Lease shall be renewed for an

         additional period of Twenty Four (24) months ("Renewed Term") on and

         subject to the same terms and conditions as set forth in the Lease,

         except as otherwise expressly provided herein:



         (a)      During the Renewed Term, Lessee hereby agrees to pay to Lessor

                  rent in the total principal sum One Hundred Eleven Thousand

                  and 00/100 Dollars ($111,000.00), with interest thereon, from

                  the date upon which the Renewed Term commences through and

                  including the last day of the Renewed Term, at a fixed

                  interest rate of Seven percent (7.0%), to be paid in Eight (8)

                  consecutive Quarterly installments of principal and interest

                  of Fourteen Thousand Seven Hundred Thirty Seven and 00/100

                  Dollars ($14,737.00) (each a "Periodic Installment") and a

                  final installment equal to the GPO Amount (as that term is

                  described below). The Periodic Installments have been

                  calculated on the basis of a 360 day year of twelve thirty-day

                  months. Each Periodic Installment may, at the option of the

                  Lessor, be calculated and applied on the assumption that such

                  installment would be made on its due date. The first Periodic

                  Installment shall be due and payable on July 1, 2003 and the

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