THIS NOTE HAS NOT BEEN REGISTERED WITH THE UNITED STATES SECURITIES AND EXCHANGE

COMMISSION OR THE SECURITIES ADMINISTRATOR OF ANY STATE PURSUANT TO AN EXEMPTION

FROM REGISTRATION UNDER REGULATION D PROMULGATED UNDER THE SECURITIES ACT OF

1933, AS AMENDED (THE "ACT"). THIS NOTE IS SUBJECT TO THE TERMS OF A NOTE

PURCHASE AGREEMENT DATED AS OF MARCH 26, 2003 AND MAY NOT BE TRANSFERRED OR SOLD

EXCEPT AS PROVIDED THEREIN AND AS PERMITTED UNDER THE ACT PURSUANT TO

REGISTRATION OR EXEMPTION THEREFROM.



                              NEOPROBE CORPORATION



                 9.5% CONVERTIBLE SECURED NOTE DUE JUNE 30, 2004



$250,000.00                                                        April 2, 2003



         FOR VALUE RECEIVED, the undersigned, NEOPROBE CORPORATION (herein

called the "COMPANY"), a corporation organized and existing under the laws of

the State of Delaware hereby promises to pay to Donald E. Garlikov, or

registered assigns, the principal sum of $250,000.00 on the earlier to occur of

(a) June 30, 2004, or (b) thirty days following such date as David C. Bupp is no

longer the chief executive officer of the Company, with interest (computed on

the basis of a 360-day year of twelve 30-day months) on the unpaid balance

thereof at the rate of 9.5% per annum from the date hereof, payable monthly in

arrears, on the last day of each calendar month, commencing with the calendar

month next succeeding the date hereof, until the principal hereof shall have

become due and payable.



         Payments of principal of, and interest on this Note are to be made in

lawful money of the United States of America at the address of the holder of

this Note provided for receipt of notices under the Note Purchase Agreement

referred to below or, at the option of the holder of this Note, in immediately

available funds at any bank or other financial institution capable of receiving

immediately available funds designated by the holder of this Note.



         This Note has been issued pursuant, and is subject, to an 9.5%

Convertible Secured Note Purchase Agreement, dated as of March 26, 2003, as the

same may be amended, modified or supplemented from time to time in accordance

with the terms thereof (the "NOTE PURCHASE AGREEMENT"), between the Company and

the Purchaser named therein and is entitled to the benefits thereof. Each holder

of this Note will be deemed, by its acceptance hereof, (a) to have agreed to all

of the terms of the Note Purchase Agreement and other agreements referenced

therein, and (b) to have made the representations and warranties set forth in

Sections 4.2 through 4.8 of the Note Purchase Agreement. This Note is secured,

among other things, pursuant to the Security Agreement as therein defined, and

may now or hereafter be secured by one or more other security agreements,

mortgages, deeds of trust, assignments or other instruments or agreements.



         This Note may be prepaid at any time prior to maturity in whole or in

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