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Press Release |
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2003 |
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7KB total |
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$37 |
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#283385 |
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[GENAERA LOGO]
FOR IMMEDIATE RELEASE
Contact:
| Genaera Corporation | The Trout Group/BMC Communications | |
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Jennifer Bilotti |
Jonathan Fassberg ext. 16 (investor inquiries) | |
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(610) 941-4020 |
Brad Miles ext. 17 (media inquiries) | |
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www.genaera.com |
(212) 477-9007 |
Genaera Announces Presentation on Preclinical Squalamine Research
-VEGF Blockade Associated with Anti-Tumor Effects-
Plymouth Meeting, PA, November 4, 2003 /PRNewswire/Genaera Corporation (NASDAQ: GENR) today announced that Richard J. Pietras, PhD, MD, Associate Professor of Medicine at the University of California, Los Angeles (UCLA) Medical Center and Jonsson Comprehensive Cancer Center will present today preclinical research on squalamine at the XVII FIGO World Congress of Gynecology and Obstetrics in Santiago, Chile. The presentation is entitled Squalamine Blocks Tumor Associated Angiogenesis and Growth of Ovarian Cancer.
The presentation highlights that the anti-angiogenic effects of squalamine correlated well with squalamine induced blockade of the rapid vascular endothelial growth factor (VEGF) stimulated phosphorylation of p42/p44 MAP kinase in endothelial cells, an early cell response to activate proliferation. Squalamine also reduced VEGF induced phophorylation of focal adhesion kinase and stress activated protein kinase-2/p38, blocking in turn assembly of F-actin stress fibers in endothelial cells. These effects follow primary interaction of squalamine with caveolar domains at surface membranes of endothelial cells, sites for the concentration of vital signaling complexes to regulate the angiogenic process. The presentation concludes that the potent anti-tumor efficacy of squalamine is due to coordinated disruption of tumor associated angiogenesis.
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