CURIS, INC.



                               Severance Agreement



     THIS SEVERANCE AGREEMENT by and between Curis, Inc., a Delaware corporation

(the "Company"), and Andrew C.G. Uprichard (the "Executive") is made as of

November 5, 2001 (the "Effective Date").



     WHEREAS, the Board of Directors of the Company (the "Board") has determined

that appropriate steps should be taken to reinforce and encourage the continued

employment and dedication of certain of the Company's key personnel; and



     WHEREAS, the Company wishes to provide the Executive with severance pay in

the event of the Executive's separation from the Company under the circumstances

provided for herein;



     NOW, THEREFORE, in consideration of the Executive's continued employment by

the Company and other good and valuable consideration, the sufficiency of which

is hereby acknowledged, the parties agree as follows:



     1. Term of Agreement. This Agreement, and all rights and obligations of the

parties hereunder, shall take effect upon the Effective Date and shall expire at

midnight on December 31, 2003 (the "Expiration Date").



     2. Not an Employment Contract. The Executive acknowledges that this

Agreement does not constitute a contract of employment or impose on the Company

any obligation to retain the Executive as an executive or employee of the

Company and that this Agreement does not prevent the Executive from terminating

his employment with the Company at any time.



     3. Termination For Cause or Voluntary Termination Without Good Reason Prior

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