$200,000,000

ABGENIX, INC.

3¹/2% Convertible Subordinated Notes Due 2007

REGISTRATION RIGHTS AGREEMENT

March 4, 2002

CREDIT SUISSE FIRST BOSTON CORPORATION
BANC OF AMERICA SECURITIES LLC
ROBERTSON STEPHENS, INC.,
    C/O CREDIT SUISSE FIRST BOSTON CORPORATION,
        ELEVEN MADISON AVENUE,
        NEW YORK, N.Y. 10010-3629

Dear Sirs:

        Abgenix, Inc., a Delaware corporation (the "Company") proposes to issue and sell to Credit Suisse First Boston Corporation, Banc of America Securities LLC and Robertson Stephens, Inc. (collectively, the "Initial Purchasers"), upon the terms set forth in a purchase agreement dated as of February 27, 2002 (the "Purchase Agreement"), $200,000,000 aggregate principal amount (plus up to an additional $50,000,000 principal amount) of its 3¹/2% Convertible Subordinated Notes due 2007 (the "Initial Securities"). The Initial Securities will be convertible into shares of common stock, par value $0.0001 per share, of the Company (the "Common Stock") at the conversion price set forth in the Offering Circular dated February 27, 2002 (the "Offering Circular"). The Initial Securities will be issued pursuant to an Indenture, dated as of the date hereof (the "Indenture"), between the Company and State Street Bank and Trust Company of California, N.A., as trustee (the "Trustee"). As an inducement to the Initial Purchasers to enter into the Purchase Agreement, the Company agrees with the Initial Purchasers, for the benefit of (i) the Initial Purchasers and (ii) the holders of the Initial Securities and the Common Stock issuable upon conversion of the Initial Securities (collectively, the "Securities") from time to time until such time as such Securities have been sold pursuant to a Shelf Registration Statement (as defined below) (each of the forgoing a "Holder" and collectively the "Holders"), as follows:

        1.    Shelf Registration.    (a) The Company shall, at its cost, prepare and, as promptly as practicable (but in no event more than 90 days after the date of this Agreement) file with the Securities and Exchange Commission (the "Commission") and thereafter use its commercially reasonable efforts to cause to be declared effective as soon as practicable after it has filed a registration statement on Form S-3 or, if Form S-3 is not available, on an appropriate form under the Securities Act (the "Shelf Registration Statement") relating to the offer and sale of the Transfer Restricted Securities (as defined in Section 5 hereof) by the Holders thereof from time to time in accordance with the methods of distribution set forth in the Shelf Registration Statement and Rule 415 under the Securities Act of 1933, as amended (the "Securities Act") (hereinafter, the "Shelf Registration"); provided, however, that no Holder (other than an Initial Purchaser) shall be entitled to have the Securities held by it covered by such Shelf Registration Statement unless such Holder agrees in writing to be bound by all the provisions of this Agreement applicable to such Holder.

        (b)  The Company shall use its commercially reasonable efforts to keep the Shelf Registration Statement continuously effective in order to permit the prospectus included therein (the "Prospectus") to be lawfully delivered by the Holders of the relevant Securities, for a period of two years (or for such longer period if extended pursuant to Section 2(h) below) from the date of this Agreement or such shorter period that will terminate when all the Securities covered by the Shelf Registration Statement (i) have been sold pursuant thereto or (ii) are no longer restricted securities (as defined in Rule 144(k)

under the Securities Act, or any successor rule thereof), assuming for this purpose that the Holders thereof are not affiliates of the Company (in any such case, such period being called the "Shelf Registration Period"). The Company shall be deemed not to have used its commercially reasonable efforts to keep the Shelf Registration Statement effective during the requisite period if it voluntarily takes any action that would result in Holders of Securities covered thereby not being able to offer and sell such Securities during that period, unless such action is (i) required by applicable law or (ii) taken by the Company in good faith and contemplated by Section 2(b)(v) below, and the Company thereafter complies with the requirements of Section 2(h).

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